NDLI: Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia

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Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia

Content Provider	Scilit
Author	Schrezenmeier, Hubert Passweg, Jakob R. Marsh, Judith C. W. Bacigalupo, Andrea Bredeson, Christopher N. Bullorsky, Eduardo Camitta, Bruce M. Champlin, Richard E. Gale, Robert Peter Fuhrer, Monika Klein, John P. Locasciulli, Anna Oneto, Rosi Schattenberg, Antonius V. M. B. Socie, Gerard Eapen, Mary
Copyright Year	2007
Description	We analyzed the outcome of 692 patients with severe aplastic anemia (SAA) receiving transplants from HLA-matched siblings. A total of 134 grafts were peripheral blood progenitor cell (PBPC) grafts, and 558 were bone marrow (BM) grafts. Rates of hematopoietic recovery and grades 2 to 4 chronic graft-versus-host disease (GVHD) were similar after PBPC and BM transplantations regardless of age at transplantation. In patients older than 20 years, chronic GVHD and overall mortality rates were similar after PBPC and BM transplantations. In patients younger than 20 years, rates of chronic GVHD (relative risk [RR] 2.82; P = .002) and overall mortality (RR 2.04; P = .024) were higher after transplantation of PBPCs than after transplantation of BM. In younger patients, the 5-year probabilities of overall survival were 73% and 85% after PBPC and BM transplantations, respectively. Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939910/pdf
Ending Page	1400
Page Count	4
Starting Page	1397
DOI	10.1182/blood-2007-03-081596
Journal	Blood
Issue Number	4
Volume Number	110
Language	English
Publisher	American Society of Hematology
Publisher Date	2007-08-15
Access Restriction	Open
Subject Keyword	Hematology Mortality Hematopoietic Bone Marrow Anemia Transplantation Gvhd Peripheral Younger Aplastic Journal: Blood (Vol- 78, Issue- 4)
Content Type	Text
Resource Type	Article

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