NDLI: Platelets: crossroads of immunity and hemostasis

Content Provider	Scilit
Author	Jenne, Craig N.
Copyright Year	2014
Description	In this issue of Blood, Koupenova and colleagues report that platelets express functional TOLL-like receptor 7 (TLR7) and contribute to host survival during viral infection.1 Through a series of experiments utilizing mice deficient for TLR7 together with adoptive transfer of wild-type platelets, Koupenova et al1 demonstrate that platelets specifically respond to viral analogs and intact virus, leading to platelet activation and binding to various leukocyte subsets. Perhaps most importantly, this platelet activation appears absolutely essential for host survival during infection with some viral pathogens such as encephalomyocarditis virus (EMCV).
Related Links	http://www.bloodjournal.org/content/bloodjournal/124/5/671.full.pdf
Ending Page	672
Page Count	2
Starting Page	671
DOI	10.1182/blood-2014-05-572875
Journal	Blood
Issue Number	5
Volume Number	124
Language	English
Publisher	American Society of Hematology
Publisher Date	2014-07-31
Access Restriction	Open
Subject Keyword	Hematology Research and Experimental Medicine Leukocyte Immunity Platelets Viral Pathogens Koupenova Infection Crossroads Tlr7 Host Survival Mice Journal: Blood (Vol- 84, Issue- 5)
Content Type	Text
Resource Type	Article

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