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Allogeneic transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Litzow, Mark R. Tarima, Sergey Pérez, Waleska S. Bolwell, Brian J. Cairo, Mitchell S. Camitta, Bruce M. Cutler, Corey S. de Lima, Marcos DiPersio, John F. Gale, Robert Peter Keating, Armand Lazarus, Hillard M. Luger, Selina Marks, David I. Maziarz, Richard T. McCarthy, Philip L. Pasquini, Marcelo C. Phillips, Gordon L. Rizzo, J. Douglas Sierra, Jorge Tallman, Martin S. Weisdorf, Daniel J. |
| Copyright Year | 2010 |
| Description | Therapy-related myelodysplastic syndromes (t-MDSs) and acute myeloid leukemia (t-AML) have a poor prognosis with conventional therapy. Encouraging results are reported after allogeneic transplantation. We analyzed outcomes in 868 persons with t-AML (n = 545) or t-MDS (n = 323) receiving allogeneic transplants from 1990 to 2004. A myeloablative regimen was used for conditioning in 77%. Treatment-related mortality (TRM) and relapse were 41% (95% confidence interval [CI], 38-44) and 27% (24-30) at 1 year and 48% (44-51) and 31% (28-34) at 5 years, respectively. Disease-free (DFS) and overall survival (OS) were 32% (95% CI, 29-36) and 37% (34-41) at 1 year and 21% (18-24) and 22% (19-26) at 5 years, respectively. In multivariate analysis, 4 risk factors had adverse impacts on DFS and OS: (1) age older than 35 years; (2) poor-risk cytogenetics; (3) t-AML not in remission or advanced t-MDS; and (4) donor other than an HLA-identical sibling or a partially or well-matched unrelated donor. Five-year survival for subjects with none, 1, 2, 3, or 4 of these risk factors was 50% (95% CI, 38-61), 26% (20-31), 21% (16-26), 10% (5-15), and 4% (0-16), respectively (P < .001). These data permit a more precise prediction of outcome and identify subjects most likely to benefit from allogeneic transplantation. |
| Related Links | http://www.bloodjournal.org/content/115/9/1850.full.pdf |
| Ending Page | 1857 |
| Page Count | 8 |
| Starting Page | 1850 |
| DOI | 10.1182/blood-2009-10-249128 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 115 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2010-03-04 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Transplantation Multivariate Analysis Aml Allogeneic Dfs Leukemia Myelodysplastic Donor Myeloid Journal: Blood (Vol- 110, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |
