NDLI: Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

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Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

Content Provider	Scilit
Author	Maeda, M. Arima, N. Daitoku, Y. Kashihara, M. Okamoto, H. Uchiyama, T. Shirono, K. Matsuoka, M. Hattori, T. Takatsuki, K.
Copyright Year	1987
Description	Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I (HTLV-I). Twenty-five patients with ATL were examined to determine whether their leukemic cells continued to show IL-2-dependent proliferation. In 21 patients, the in vitro proliferation of HTLV-I-infected nonleukemic T cell clones was found to be dependent on IL-2. However, clonality analysis based on T cell receptor gene rearrangement profiles and the site of HTLV-I provirus integration revealed IL-2-dependent growth in leukemic cells in four patients with ATL. These results provide evidence for the IL-2- dependent proliferation of leukemic cells in some ATL patients.
Related Links	https://ashpublications.org/blood/article-pdf/70/5/1407/365673/1407.pdf
Ending Page	1411
Page Count	5
Starting Page	1407
DOI	10.1182/blood.v70.5.1407.bloodjournal7051407
Journal	Blood
Issue Number	5
Volume Number	70
Language	English
Publisher	American Society of Hematology
Publisher Date	1987-11-01
Access Restriction	Open
Subject Keyword	Virology Virus Proliferation Leukemia Evidence Antigen Htlv Leukemic Cells Adult T Cell Journal: Blood (Vol- 82, Issue- 5)
Content Type	Text
Resource Type	Article

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