Loading...
Please wait, while we are loading the content...
Similar Documents
Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors
| Content Provider | Scilit |
|---|---|
| Author | Dagklis, Antonis Demeyer, Sofie Bie, Jolien De Radaelli, Enrico Pauwels, Daphnie Degryse, Sandrine Gielen, Olga Vicente, Carmen Vandepoel, Roel Geerdens, Ellen Uyttebroeck, Anne Boeckx, Nancy Bock, Charles E. De Cools, Jan |
| Copyright Year | 2016 |
| Description | Key Points A subset of T-ALL cases show high expression of hedgehog pathway genes including the SHH ligand and the GLI1 transcription factor. T-ALL samples with high GLI1 expression levels respond to hedgehog inhibitor treatment in vitro and in vivo. |
| Related Links | http://www.bloodjournal.org/content/128/23/2642.full.pdf |
| Ending Page | 2654 |
| Page Count | 13 |
| Starting Page | 2642 |
| DOI | 10.1182/blood-2016-03-703454 |
| Journal | Blood |
| Issue Number | 23 |
| Volume Number | 128 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2016-12-08 |
| Access Restriction | Open |
| Subject Keyword | Oncology Proliferation Acute Lymphoblastic Leukemia Gli1 Ihh Hedgehog Pathway Activation Cell Acute Lymphoblastic Journal: Blood (Vol- 137, Issue- 23) |
| Content Type | Text |
| Resource Type | Article |