NDLI: Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

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Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

Content Provider	Scilit
Author	Leonard, Jp Quinto, Cm Kozitza, Mk Neben, Ty Goldman, Sj
Copyright Year	1994
Description	Interleukin-11 (IL-11) is a novel multifunctional hematopoietic cytokine capable of stimulating cells of the myeloid, lymphoid, erythroid, and megakaryocytic lineages in vitro. We have tested the pleiotropic properties of this cytokine on the hematopoietic recovery of mice after a combined regimen of sublethal irradiation and carboplatin administration. This regimen results in severe myelosuppression, characterized by a prolonged period of thrombocytopenia and severe anemia. Administration of recombinant human IL-11 (rhIL-11; 250 micrograms/kg/d) had multilineage effects on bone marrow and spleen hematopoietic activity, increasing the number of megakaryocyte, erythroid, granulocyte, and macrophage progenitors compared with the vehicle-treated controls. This was reflected in the peripheral circulation by a reduction of both the platelet and hematocrit nadirs and a significantly reduced period of thrombocytopenia and anemia in the rhIL-11-treated mice. The results from this study support the broad spectrum of biologic activities that have been attributed to rhIL-11 in vitro and suggest that this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation.
Related Links	https://ashpublications.org/blood/article-pdf/83/6/1499/612767/1499.pdf
Ending Page	1506
Page Count	8
Starting Page	1499
DOI	10.1182/blood.v83.6.1499.1499
Journal	Blood
Issue Number	6
Volume Number	83
Language	English
Publisher	American Society of Hematology
Publisher Date	1994-03-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Treatment Hematopoietic Bone Marrow Sublethal Myelosuppression Carboplatin Administration Vitro Rhil Stimulates Journal: Blood (Vol- 89, Issue- 6)
Content Type	Text
Resource Type	Article

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