NDLI: ADP and epinephrine-induced release of platelet fibrinogen

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ADP and epinephrine-induced release of platelet fibrinogen

Content Provider	Scilit
Author	Kaplan, Kl Dauzier, Mj Rose, S.
Copyright Year	1981
Description	Human platelets gel-filtered into Tyrode's buffer containing 1 mM Mg++ and 0.35% bovine serum albumin were studied to determine whether they would undergo biphasic aggregation and release of alpha-granule proteins in response to adenosine diphosphate (ADP) or epinephrine without addition of exogenous fibrinogen. Fibrinogen concentration in the supernatant of unaggregated gel-filtered platelets was less than 1 pmole/ml. With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4. Fibrinogen concentration in the supernatant after aggregation ranged from 15 to 70 pmole/ml. Release of the alpha-granule proteins by epinephrine was coincidental with release of the dense granule adenine nucleotides. Aggregation and alpha-granule protein release by both ADP and epinephrine were inhibited by added Ca++ at 1-- 2 mM. The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.
Related Links	https://ashpublications.org/blood/article-pdf/58/4/797/208912/797.pdf
Ending Page	802
Page Count	6
Starting Page	797
DOI	10.1182/blood.v58.4.797.bloodjournal584797
Journal	Blood
Issue Number	4
Volume Number	58
Language	English
Publisher	American Society of Hematology
Publisher Date	1981-10-01
Access Restriction	Open
Subject Keyword	Anesthesiology Epinephrine Proteins Fibrinogen Adp Gel Filtered Platelets Journal: Blood (Vol- 74, Issue- 4)
Content Type	Text
Resource Type	Article

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