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High frequency of protein Z deficiency in patients with unexplained early fetal loss
| Content Provider | Scilit |
|---|---|
| Author | Gris, Jean-Christophe Quere, Isabelle Dechaud, Hervé Mercier, Eric Pinçon, Caroline Hoffet, Médéric Vasse, Marc Marès, Pierre |
| Copyright Year | 2002 |
| Description | The protein Z–protein Z-dependent inhibitor complex is a factor Xa inhibitor. Protein Z deficiencies have recently been described in patients with ischemic stroke. As placenta infarction leads to poor pregnancy outcome, we studied protein Z plasma concentrations in nonthrombotic, nonthrombophilic consecutive patients with unexplained pregnancy wastage. A significant amount of protein Z deficiencies was only found in the early fetal loss group (< 1 mg/L; 44 of 200,P < 10−4) and mainly in the case of fetal demise between the beginning of the 10th and the end of the 15th week of gestation (odds ratio, 6.7 [3.1-14.8],P < 10−3). These deficiencies were not due to partial vitamin K1 deficiency, and at least some of them were constitutional ones. In women, protein Z deficiency may induce an enhanced risk of severe placental insufficiency soon after the connection of maternal and fetal circulations. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/99/7/2606.full.pdf |
| Ending Page | 2608 |
| Page Count | 3 |
| Starting Page | 2606 |
| DOI | 10.1182/blood.v99.7.2606 |
| Journal | Blood |
| Issue Number | 7 |
| Volume Number | 99 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2002-04-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Pregnancy Loss Unexplained Fetal Protein Z Deficiency Löß Journal: Blood (Vol- 99, Issue- 7) |
| Content Type | Text |
| Resource Type | Article |
