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The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns
| Content Provider | Scilit |
|---|---|
| Author | Alter, Bp |
| Copyright Year | 1979 |
| Description | To determine whether the G gamma:A gamma HbF switch is coordinated in development with the HbF:HbA switch, hemoglobin F Gly/Ala (G gamma:A gamma) heterogeneity was evaluated by electrophoresis on polyacrylamide gels. The mean G gamma was 70% in 19 newborns, similar to the published value of 73% obtained by amino acid analysis of the gamma CG-3 peptide. In 29 fetuses at 18–20-wk gestation, G gamma was 71%. The values were similar in normal fetuses and newborns and in those with hemoglobinopathies. The synthetic ratio of 3H-leucine-labeled G gamma:A gamma was identical to the ratio found in the globin protein accumulated by 20 wk. The proportion of G gamma was also identical in 6 paired samples, at 20-wk gestation and at birth. Thus, G gamma production does not decline with respect to A gamma in utero at the time of onset of the HbF:HbA switch. |
| Related Links | https://ashpublications.org/blood/article-pdf/54/5/1158/582508/1158.pdf |
| Ending Page | 1163 |
| Page Count | 6 |
| Starting Page | 1158 |
| DOI | 10.1182/blood.v54.5.1158.1158 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 54 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1979-11-01 |
| Access Restriction | Open |
| Subject Keyword | Physiology Electrophoresis Leucine Birth Fetuses Hbf Gamma Newborns Switch Decline Coordinated Journal: Blood (Vol- 80, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
