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Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies
| Content Provider | Scilit |
|---|---|
| Author | Sobol, Re Royston, I. LeBien, Tw Minowada, J. Anderson, K. Davey, Fr Cuttner, J. Schiffer, C. Ellison, Rr Bloomfield, Cd |
| Copyright Year | 1985 |
| Description | Pretreatment peripheral blood and/or bone marrow blasts from 90 adults with acute lymphoblastic leukemia (ALL) were analyzed as part of a prospective treatment protocol study. Specimens were tested by immunofluorescence cytofluorometry for reactivity with the following monoclonal antibodies (MoAbs): BA-1 (B cell antigen); T101, OKT11 (pan- T cell antigens [T]); 3A1 (T cell antigen); MCS-2 (myeloid antigen); J5 common ALL antigen (CALLA); BA4 (Ia antigen [Ia]); BA-2 (lymphohematopoietic antigen). Four major phenotypic groups were identified: B lineage ALL (BA-1+T-) (64%), T lineage ALL (T+BA-1-MCS-2- ) (13%), unclassified ALL (BA-1-MCS-2-CALLA-T-) (9%) and myeloid antigen ALL (MCS-2+CALLA-T-) (7%). An additional group of patients, miscellaneous ALL (7%), was comprised of cases with unusual marker profiles. In B lineage ALL, all cases tested were Ia+MCS-2-, and the vast majority were CALLA+ (84%). In T lineage ALL, 42% expressed CALLA or Ia positivity. In unclassified ALL, the predominant phenotype was Ia+BA-2+. In myeloid antigen ALL, two of four tested were 3A1+ and all cases evaluated were BA-1-. Patients with myeloid antigen ALL were older (median age, 66 years) than patients in the other groups. The T lineage ALL group had higher leukocyte counts (median WBCs, 183,000/microL) and an increased incidence of anterior mediastinal mass at presentation. All patients received identical induction therapy. In CALLA+B lineage ALL, 30 of 46 (65%) achieved a complete remission. While the number of patients evaluated was small, 9 of 9 CALLA-B- lineage ALL and only two of six myeloid antigen ALL cases responded with a complete remission. The data suggest that these MoAbs are useful in the characterization of adult ALL. |
| Related Links | https://ashpublications.org/blood/article-pdf/65/3/730/361925/730.pdf |
| Ending Page | 735 |
| Page Count | 6 |
| Starting Page | 730 |
| DOI | 10.1182/blood.v65.3.730.bloodjournal653730 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 65 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1985-03-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Antibodies Bone Marrow Adults Mcs Myeloid Antigen Journal: Blood (Vol- 66, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
