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Allogeneic CAR19 cells clear ALL
| Content Provider | Scilit |
|---|---|
| Author | Neeson, Paul |
| Copyright Year | 2016 |
| Description | Chimeric antigen receptor T cells redirected to CD19 (chimeric antigen receptor [CAR19]) show great promise in the clinic to treat refractory CD19+ acute lymphoblastic leukemia (ALL). However, production of autologous CAR19 cells from these patients can be difficult as patients frequently have T-cell dysfunction, due to disease and/or treatment-related effects. In this issue of Blood, Jacoby et al1 addressed this by exploring whether allogeneic donor CAR19 cells could be used to treat ALL-bearing mice using a minor mismatch bone marrow transplant model. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/127/10/1224.full.pdf |
| Ending Page | 1225 |
| Page Count | 2 |
| Starting Page | 1224 |
| DOI | 10.1182/blood-2016-01-687681 |
| Journal | Blood |
| Issue Number | 10 |
| Volume Number | 127 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2016-03-10 |
| Access Restriction | Open |
| Subject Keyword | Hematology Research and Experimental Medicine Allogeneic Car19 Cells Clear Journal: Blood (Vol- 114, Issue- 10) |
| Content Type | Text |
| Resource Type | Article |