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Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Hegde, Upendra P. Wilson, Wyndham H. White, Therese Cheson, Bruce D. |
| Copyright Year | 2002 |
| Description | Fludarabine can exacerbate idiopathic thrombocytopenia (ITP) in chronic lymphocytic leukemia (CLL). We report 3 CLL patients with refractory fludarabine-associated ITP who responded to rituximab. The patients had Rai stages III, III, and IV disease. Before fludarabine treatment, the platelet counts were 141 000/μL, 118 000/μL, and 70 000/μL. ITP developed within week 1 of cycle 3 in 2 patients and within week 2 of cycle 1 in 1 patient. Platelet count nadirs were 4000/μL, 1000/μL, and 2000/μL, respectively, and did not respond to treatment with steroids or intravenous immunoglobulin. Rituximab therapy (375 mg/m2 per week for 4 weeks) was begun on days 18, 23, and 20 of ITP. Patient 1 achieved a platelet count of more than 50 000/μL at day 21 and more than 133 000/μL at day 28, patient 2 achieved a platelet count of more than 50 000/μL at day 4 and more than 150 000/μL at day 10, and patient 3 achieved a platelet count of more than 50 000/μL at day 5 and 72 000/μL at day 28 of rituximab therapy, with platelet response durations of 17+, 6+, and 6 months. These results suggest rituximab can rapidly reverse refractory fludarabine-associated ITP. |
| Related Links | https://ashpublications.org/blood/article-pdf/100/6/2260/43024/h81802002260.pdf |
| Ending Page | 2262 |
| Page Count | 3 |
| Starting Page | 2260 |
| DOI | 10.1182/blood.v100.6.2260.h81802002260_2260_2262 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 100 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2002-09-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Refractory Platelet Leukemia Itp Lymphocytic Rituximab Cll Fludarabine Iii Journal: Blood (Vol- 90, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
