NDLI: Thrombin-induced changes in platelet membrane glycoproteins Ib, IX, and IIb-IIIa complex

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Thrombin-induced changes in platelet membrane glycoproteins Ib, IX, and IIb-IIIa complex

Content Provider	Scilit
Author	Barnard Michelson, Ad
Copyright Year	1987
Description	Platelet membrane glycoprotein Ib (GPIb) and the GPIIb-IIIa complex have central roles in the interaction of platelets with the plasma coagulation system, damaged vessel walls, and other platelets. We investigated the effects of thrombin on these glycoproteins. Monoclonal antibodies were used to assess platelet surface glycoproteins by flow cytometry, total platelet glycoprotein content by immunoassay, and glycoproteins released from platelets, also by immunoassay. Five new observations were made with regard to thrombin-induced changes in platelet membrane glycoproteins: (a) The marked decrease in platelet surface binding of antibodies directed at GPIb was not confined to antibodies directed at the von Willebrand factor binding site. (b) There was a marked decrease in platelet surface binding of an antibody directed at GPIX, with maintenance of the 1:1 ratio of platelet surface binding of antibodies directed at GPIb and GPIX. (c) Changes in platelet surface binding of antibodies were not restricted to a distinct subpopulation of platelets. (d) There was no associated platelet release of glycocalicin (a proteolytic fragment of GPIb). (e) There was no associated platelet release of the GPIIb-IIIa complex. These thrombin-induced changes may be important in modulating the reactivity of platelets with the damaged vessel wall and with each other.
Related Links	https://ashpublications.org/blood/article-pdf/70/5/1673/365568/1673.pdf
Ending Page	1678
Page Count	6
Starting Page	1673
DOI	10.1182/blood.v70.5.1673.bloodjournal7051673
Journal	Blood
Issue Number	5
Volume Number	70
Language	English
Publisher	American Society of Hematology
Publisher Date	1987-11-01
Access Restriction	Open
Subject Keyword	Hematology Medical Laboratory Technology Glycoproteins Immunoassay Gpib Gpix Surface Binding Antibodies Directed Changes in Platelet Journal: Blood (Vol- 82, Issue- 5)
Content Type	Text
Resource Type	Article

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