NDLI: Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL

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Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL

Content Provider	Scilit
Author	Alves, Catarina Castro Terziyska, Nadia Grunert, Michaela Gündisch, Sibylle Graubner, Ulrike Quintanilla-Martinez, Leticia Jeremias, Irmela
Copyright Year	2012
Description	Cancer stem cells represent the most important target cells for antitumor therapy. TRAIL (TNF-related apoptosis-inducing ligand) is a potential anticancer agent that induces apoptosis in a wide variety of tumor cells, but its ability to target cancer stem cells is currently unknown. Here we investigated whether TRAIL targets leukemia-initiating cells. Limiting dilution transplantation assays were performed on xenografts from pediatric patients with precursor B-cell acute lymphoblastic leukemia (pre-B ALL) in NSG mice. In vitro treatment of xenograft cells with TRAIL significantly reduced and delayed their engraftment and procrastinated animal death from leukemia. Systemic TRAIL treatment of mice injected with patient-derived pre-B ALL xenograft cells abrogated leukemia in 3 of 5 mice in 1 sample. In conclusion, our data suggest that TRAIL targets leukemia-initiating cells derived from pre-B ALL xenografts in vitro and in vivo, and hence constitutes an attractive candidate drug for treatment of ALL.
Related Links	https://ashpublications.org/blood/article-pdf/119/18/4224/1351931/zh801812004224.pdf
Ending Page	4227
Page Count	4
Starting Page	4224
DOI	10.1182/blood-2011-08-370114
Journal	Blood
Issue Number	18
Volume Number	119
Language	English
Publisher	American Society of Hematology
Publisher Date	2012-05-03
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Cancer Stem Cells Apoptosis Anticancer Trail Acute Lymphoblastic Leukemia Pediatric Xenograft Cells Journal: Blood (Vol- 129, Issue- 18)
Content Type	Text
Resource Type	Article

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