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Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
| Content Provider | Scilit |
|---|---|
| Author | Borsotti, Chiara Franklin, Anna R. K. Lu, Sydney X. Kim, Theo D. Smith, Odette M. Suh, David King, Chris G. Chow, Andrew Liu, Chen Alpdogan, Onder Brink, Marcel R. M. Van Den |
| Copyright Year | 2007 |
| Description | Tumor necrosis factor (TNF) plays an important role in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) activity after allogeneic bone marrow transplantation (allo-BMT). TNF can be expressed in a membrane-bound form (memTNF) and as a soluble (solTNF) molecule after being cleaved by the TNF-α converting enzyme (TACE). To study the contribution of donor T-cell–derived memTNF versus solTNF in GVHD and GVT, we used mice containing a noncleavable allele in place of endogenous TNF (memTNFΔ/Δ) as donors in murine BMT models. Recipients of memTNF T cells developed significantly less GVHD than recipients of wild-type (wt) T cells. In contrast, GVT activity mediated by memTNF T cells remained intact, and alloreactive memTNF T cells showed no defects in proliferation, activation, and cytotoxicity. These data suggest that suppressing the secretion of solTNF by donor T cells significantly decreases GVHD without impairing GVT activity. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/110/2/783.full.pdf |
| Ending Page | 786 |
| Page Count | 4 |
| Starting Page | 783 |
| DOI | 10.1182/blood-2006-10-054510 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 110 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2007-07-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Allele Gvhd Gvt Bone Marrow Transplantation Memtnf Allogeneic Graft Versus Tumor Journal: Blood (Vol- 60, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
