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Prothrombotic lipoprotein patterns in stroke
| Content Provider | Scilit |
|---|---|
| Author | Podrez, Eugene A. Byzova, Tatiana V. |
| Copyright Year | 2016 |
| Description | The importance of research focused on the final events of atherothrombosis cannot be overestimated. Platelet hyperreactivity leading to thrombosis is the main reason for mortality and morbidity in patients with cardiovascular disease and stroke, which together remain a leading cause of death in developed countries. In this issue of Blood, Shen et $al^{1}$ establish another functional link between proatherogenic lipoproteins and platelet-mediated thrombus formation with a specific focus on stroke. In their model, the initiating component is L5, the electronegative subfraction of low-density lipoproteins (LDLs), which was shown to be substantially elevated in patients with ischemic stroke. L5 was shown to activate platelets via its receptor, lectin-like oxidized LDL receptor-1 (LOX-1), and αβ amyloid peptide, which together contribute to platelet hyperreactivity and stroke complications. |
| Related Links | https://ashpublications.org/blood/article-pdf/127/10/1221/1391517/1221.pdf |
| Ending Page | 1222 |
| Page Count | 2 |
| Starting Page | 1221 |
| DOI | 10.1182/blood-2016-01-689034 |
| Journal | Blood |
| Issue Number | 10 |
| Volume Number | 127 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2016-03-10 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Prothrombotic Lipoprotein Patterns in Stroke Journal: Blood (Vol- 114, Issue- 10) |
| Content Type | Text |
| Resource Type | Article |
