Loading...
Please wait, while we are loading the content...
Similar Documents
Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide
| Content Provider | Scilit |
|---|---|
| Author | Clift, Ra Buckner, Cd Thomas, Ed Bensinger, W. I. Bowden, R. Bryant, E. Deeg, H. J. Doney, Kc Fisher, Ld Hansen, Ja |
| Copyright Year | 1994 |
| Description | A prospective randomized study was conducted comparing two conditioning regimens for the treatment of patients with chronic myeloid leukemia in chronic phase by marrow transplantation from HLA identical siblings. Sixty-nine patients received 60 mg/kg of cyclophosphamide on each of 2 successive days followed by 6 fractions of total body irradiation each of 2.0 Gy (CY-TBI), and 73 patients received 16 mg/kg of busulfan delivered over 4 days followed by 60 mg/kg CY on each of 2 successive days (BU-CY). There was no significant difference between the CY-TBI and the BU-CY groups in the 3-year probabilities of survival (0.80 for both), relapse (0.13 for both), or event-free survival (CY-TBI, 0.68; BU-CY, 0.71) or in speed of engraftment or incidence of venocclusive disease of the liver. The 4-year probabilities of survival and event- free survival for patients transplanted within 1 year of diagnosis were 0.86 and 0.72, respectively, for each group. Significantly more patients in the CY-TBI group experienced major creatinine elevations. There was significantly more acute graft-versus-host disease in the CY- TBI group. Fever days, positive blood cultures, hospitalizations, and inpatient hospital days were significantly more common in the CY-TBI group than in the BU-CY group. In conclusion, the BU-CY regimen was better tolerated than, and associated with survival and relapse probabilities that compare favorably with, the CY-TBI regimen. |
| Related Links | https://ashpublications.org/blood/article-pdf/84/6/2036/615959/2036.pdf |
| Ending Page | 2043 |
| Page Count | 8 |
| Starting Page | 2036 |
| DOI | 10.1182/blood.v84.6.2036.2036 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 84 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1994-09-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Survival Transplantation Tbi Cyclophosphamide Tolerated Mg/kg Bu Cy Journal: Blood (Vol- 89, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
