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High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1–specific CTL response
| Content Provider | Scilit |
|---|---|
| Author | Toulza, Frederic Heaps, Adrian Tanaka, Yuetsu Taylor, Graham P. Bangham, Charles R. M. |
| Copyright Year | 2008 |
| Description | Evidence from population genetics, gene expression microarrays, and assays of ex vivo T-cell function indicates that the cytotoxic T lymphocyte (CTL) response to human T-lymphotropic virus type 1 (HTLV-1) controls the level of HTLV-1 expression and the proviral load. The rate at which CTLs kill autologous HTLV-1–infected lymphocytes differs significantly among infected people, but the reasons for such variation are unknown. Here, we demonstrate a strong negative cor-relation between the frequency of CD4+FoxP3+ Tax− regulatory T cells (Tregs) in the circulation and the rate of CTL-mediated lysis of autologous HTLV-1–infected cells ex vivo. We propose that the frequency of CD4+FoxP3+ Tax− Tregs is one of the chief determinants of the efficiency of T cell–mediated immune control of HTLV-1. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602587/pdf |
| Ending Page | 5053 |
| Page Count | 7 |
| Starting Page | 5047 |
| DOI | 10.1182/blood-2007-10-118539 |
| Journal | Blood |
| Issue Number | 10 |
| Volume Number | 111 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2008-05-15 |
| Access Restriction | Open |
| Subject Keyword | Virology High Frequency Journal: Blood (Vol- 114, Issue- 10) |
| Content Type | Text |
| Resource Type | Article |
