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Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes
| Content Provider | Scilit |
|---|---|
| Author | Voso, Maria Teresa Scardocci, Alessandra Guidi, Francesco Zini, Gina Mario, Antonella Di Pagano, Livio Hohaus, Stefan Leone, Giuseppe |
| Copyright Year | 2004 |
| Description | Death-associated protein kinase (DAP-kinase), a proapoptotic serine/threonine kinase, is a candidate tumor suppressor gene. We studied the methylation status of DAP-kinase of 194 bone marrow samples from 160 patients with acute myeloid leukemia (AML) and 34 with a myelodysplastic syndrome (MDS) at the time of initial diagnosis by polymerase chain reaction (PCR). Hypermethylation of DAP-kinase was present in 27.5% (44 of 160) of AML and in 47% (16 of 34) of MDS specimens and significantly correlated to loss of DAP-kinase expression (P = .008). It was significantly more frequent in AML secondary to therapy for other malignancies (s-AML; 14 of 29, 48.3%), as compared to de novo AML (30 of 131, 22.9%, P = .01). DAP-kinase hypermethylation in AML was associated with myelodysplastic changes in the bone marrow at the time of the initial diagnosis (P = .002) and with the presence of cytogenetic abnormalities (P = .02). Alteration in the apoptotic response due to the loss of DAP-kinase function may be an early event in the transformation pathway to secondary leukemia via myelodysplasia. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/103/2/698.full.pdf |
| Ending Page | 700 |
| Page Count | 3 |
| Starting Page | 698 |
| DOI | 10.1182/blood-2003-07-2249 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 103 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2004-01-15 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Methylation Bone Marrow Aml Dap Kinase Protein Function Mds Myelodysplastic Journal: Blood (Vol- 59, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
