NDLI: A New Human Low Molecular Weight Granulocyte Colony Stimulating Activity

Please wait, while we are loading the content...

A New Human Low Molecular Weight Granulocyte Colony Stimulating Activity

Content Provider	Scilit
Author	Price, G. B. McCulloch, M. D. E. A. Till, J. E.
Copyright Year	1973
Description	Fractionation of conditioned medium derived from cultures of human peripheral blood leukocytes by ultrafiltration yielded material of low molecular weight, capable of stimulating the formation of granulopoietic colonies by human marrow cells in culture. The molecular weight of the active material was found to be less than that of vitamin B12 (1330 mol wt) on the basis of gel filtration on Sephadex G-25. The low molecular weight colony-stimulating activity (LMW-CSA) was trypsin-sensitive, and extractable into chloroform or diethyl ether. Unlike unfractionated leukocyte-conditioned medium, the LMW-CSA showed no colony-stimulating activity when tested on mouse, rather than human, marrow cell cultures.
Related Links	https://ashpublications.org/blood/article-pdf/42/3/341/578157/341.pdf
Ending Page	348
Page Count	8
Starting Page	341
DOI	10.1182/blood.v42.3.341.341
Journal	Blood
Issue Number	3
Volume Number	42
Language	English
Publisher	American Society of Hematology
Publisher Date	1973-09-01
Access Restriction	Open
Subject Keyword	Biochemical Research Leukocyte Molecular Weight Conditioned Medium Cells in Culture Colony Stimulating Activity Journal: Blood (Vol- 63, Issue- 3)
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in