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Platelet-derived VWF in the stroke spotlight
| Content Provider | Scilit |
|---|---|
| Author | Flood, Veronica H. |
| Copyright Year | 2015 |
| Description | In this issue of Blood, Verhenne et al present data showing the role of platelet-derived von Willebrand factor (VWF) in mediating ischemic stroke injury using a murine $model.^{1}$ They created mice with either endothelial VWF or platelet-derived VWF and examined each phenotype for bleeding and thrombosis. Their intriguing findings were that mice lacking platelet-derived VWF, but with adequate endothelial VWF stores, demonstrated normal hemostasis in a tail bleeding model and normal carotid artery thrombosis. Mice with only platelet-derived VWF had defective hemostasis and defective carotid artery thrombosis, but experienced significant cerebral infarction using a stroke model with middle cerebral artery occlusion (see figure). In contrast, minimal infarcts were seen for VWF-deficient mice. These data suggest that platelet-derived VWF plays a specific role in stroke pathology. |
| Related Links | https://ashpublications.org/blood/article-pdf/126/14/1640/1388789/1640.pdf |
| Ending Page | 1641 |
| Page Count | 2 |
| Starting Page | 1640 |
| DOI | 10.1182/blood-2015-08-661439 |
| Journal | Blood |
| Issue Number | 14 |
| Volume Number | 126 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2015-10-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Cerebral Infarction Stroke Mice Carotid Artery Platelet Derived Vwf Verhenne Journal: Blood (Vol- 124, Issue- 14) |
| Content Type | Text |
| Resource Type | Article |
