NDLI: Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan

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Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan

Content Provider	Scilit
Author	Narimatsu, Hiroto Miyakoshi, Shigesaburo Yamaguchi, Takuhiro Kami, Masahiro Matsumura, Tomoko Yuji, Koichiro Murashige, Naoko Kusumi, Eiji Kodama, Yuko Komatsu, Tsunehiko Sakamaki, Hisashi Kouzai, Yasushi Okada, Masaya Osugi, Yuko Kobayashi, Ryoji Inoue, Masami Takahashi, Satoshi Kai, Shunro Kato, Koji Inoue-Nagamura, Tokiko Taniguchi, Shuichi Kato, Shunichi
Copyright Year	2008
Description	We have little information on chronic graft-versus-host disease (GVHD) after cord blood transplantation (CBT). We investigated its clinical features in 1072 Japanese patients with hematologic malignancies who received a transplant through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 years after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated with both overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD: higher patient body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis, and development of grades II to IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects.
Related Links	http://bloodjournal.hematologylibrary.org/content/112/6/2579.full.pdf
Ending Page	2582
Page Count	4
Starting Page	2579
DOI	10.1182/blood-2007-11-118893
Journal	Blood
Issue Number	6
Volume Number	112
Language	English
Publisher	American Society of Hematology
Publisher Date	2008-09-15
Access Restriction	Open
Subject Keyword	Hematology Prophylaxis Multivariate Analysis Cbt Gvhd Japan Survival Survey Antigens Transplantation Cord Journal: Blood (Vol- 90, Issue- 6)
Content Type	Text
Resource Type	Article

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