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Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium
| Content Provider | Scilit |
|---|---|
| Author | Weiss, H. J. Turitto, Vt |
| Copyright Year | 1979 |
| Description | Prostaglandin I2 (prostacyclin, PGI2), a substance synthesized in the wall of blood vessels, has been previously shown to inhibit the aggregation of platelets in stirred platelet-rich plasma. We used a method in which segments of deendothelialized rabbit aorta are perfused at arterial shear rates with human blood and found that both platelet adhesion and thrombus formation on subendothelium was inhibited in blood containing 10 nM PGI2. PGI2 appears to reduce adhesion by inhibiting platelet spreading. These findings suggest that PGI2 could regulate the deposition of platelets on vascular surfaces. |
| Related Links | https://ashpublications.org/blood/article-pdf/53/2/244/581766/244.pdf |
| Ending Page | 250 |
| Page Count | 7 |
| Starting Page | 244 |
| DOI | 10.1182/blood.v53.2.244.244 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 53 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1979-02-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Prostaglandin I2 Prostacyclin Pgi2 Thrombus Formation Platelet Adhesion Inhibits Platelet Journal: Blood (Vol- 48, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
