NDLI: Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer

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Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer

Content Provider	Scilit
Author	Moris, Arnaud Pajot, Anthony Blanchet, Fabien Guivel-Benhassine, Florence Salcedo, Margarita Schwartz, Olivier
Copyright Year	2006
Description	Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen.
Related Links	http://pdfs.semanticscholar.org/c7c7/fbc56ebdd3aa1f32fba2cb7b8136a5651942.pdf
Ending Page	1651
Page Count	9
Starting Page	1643
DOI	10.1182/blood-2006-02-006361
Journal	Blood
Issue Number	5
Volume Number	108
Language	English
Publisher	American Society of Hematology
Publisher Date	2006-09-01
Access Restriction	Open
Subject Keyword	Virology Viral Replication Cd4 Preferential Dcs Virus Hiv Antigen Presentation Journal: Blood (Vol- 84, Issue- 5)
Content Type	Text
Resource Type	Article

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