NDLI: Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype

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Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype

Content Provider	Scilit
Author	Rao, N. Whitsett, Cf Oxendine, Sm Telen, Mj
Copyright Year	1993
Description	The Cartwright (Yt) blood group antigens have previously been shown likely to reside on a phosphatidylinositol-linked erythrocyte membrane protein. In this study, an unusual individual whose red blood cells (RBCs) were of the previously unreported Yt(a-b-) phenotype were used, along with normal Yt(a+) cells, to investigate serologically and biochemically the relationship of the Yta antigen to known phosphatidylinositol-linked erythrocyte proteins. Yt(a-b-) RBCs expressed normal amounts of various phosphatidyl-inositol-linked proteins except acetylcholinesterase. Further, human anti-Yta reacted with acetylcholinesterase in immunoprecipitation and immunoblotting studies. Thus, acetylcholinesterase is now identified as the protein bearing the Yt blood group antigens.
Related Links	https://ashpublications.org/blood/article-pdf/81/3/815/609940/815.pdf
Ending Page	819
Page Count	5
Starting Page	815
DOI	10.1182/blood.v81.3.815.815
Journal	Blood
Issue Number	3
Volume Number	81
Language	English
Publisher	American Society of Hematology
Publisher Date	1993-02-01
Access Restriction	Open
Subject Keyword	Analytical Chemistry Immunoblotting Proteins Acetylcholinesterase Erythrocyte Blood Group Antigens Yta Journal: Blood (Vol- 69, Issue- 3)
Content Type	Text
Resource Type	Article

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