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Cul4A is required for hematopoietic stem-cell engraftment and self-renewal
| Content Provider | Scilit |
|---|---|
| Author | Li, Binghui Jia, Nan Waning, David L. Yang, Feng-Chun Haneline, Laura S. Chun, Kristin T. |
| Copyright Year | 2007 |
| Description | Several hematopoietic stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway might modulate HSC function. However, this hypothesis has not been formally tested. Cul4A encodes a core subunit of one ubiquitin ligase. Whereas Cul4A-deficient embryos die in utero, Cul4A-haploinsufficient mice are viable but exhibit abnormal hematopoiesis (fewer erythroid and primitive myeloid progenitors). Given these data, we examined whether Cul4A+/− HSCs might also be impaired. Using bone marrow transplantation assays, we determined that Cul4A+/− HSCs exhibit defects in engraftment and self-renewal capacity. These studies are the first to demonstrate that ubiquitin-mediated protein degradation is important for HSC function. Further, they indicate that a Cul4A ubiquitin ligase targets for degradation one or multiple HSC regulators. |
| Related Links | http://www.bloodjournal.org/content/110/7/2704.full.pdf |
| Ending Page | 2707 |
| Page Count | 4 |
| Starting Page | 2704 |
| DOI | 10.1182/blood-2006-12-064154 |
| Journal | Blood |
| Issue Number | 7 |
| Volume Number | 110 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2007-10-01 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Hematopoietic Bone Marrow Viable Cul4a Hsc Function Ubiquitin Mediated Engraftment and Self Renewal Journal: Blood (Vol- 99, Issue- 7) |
| Content Type | Text |
| Resource Type | Article |
