NDLI: Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

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Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

Content Provider	Scilit
Author	Welniak, Lisbeth A. Kuprash, Dmitry V. Tumanov, Alexei V. Panoskaltsis-Mortari, Angela Blazar, Bruce R. Sun, Kai Nedospasov, Sergei A. Murphy, William J.
Copyright Year	2006
Description	Graft-versus-host disease (GVHD) is a multistep disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)–deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)–mismatched grafts into myeloablated TNF knockout recipients. No differences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNF-α is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT.
Related Links	http://www.bloodjournal.org/content/bloodjournal/107/1/410.full.pdf
Ending Page	412
Page Count	3
Starting Page	410
DOI	10.1182/blood-2004-11-4565
Journal	Blood
Issue Number	1
Volume Number	107
Language	English
Publisher	American Society of Hematology
Publisher Date	2006-01-01
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Bone Marrow Graft Defects Recipients Survival Tnf Gvhd Pps Acute Induction Journal: Blood (Vol- 16, Issue- 1)
Content Type	Text
Resource Type	Article

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