NDLI: Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase

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Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase

Content Provider	Scilit
Author	Wiedmer, T. Esmon, Ct Sims, Pj
Copyright Year	1986
Description	The capacity of platelets treated with nonlytic concentrations of the C5b-9 proteins to catalyze prothrombin activation and thereby trigger clot formation has been investigated. When suspended in the presence of exogenous factors Xa and Va, gel-filtered platelets treated with purified C5b-9 proteins catalyzed prothrombin to thrombin conversion at rates up to tenfold above controls, and exceeded by up to fourfold the prothrombinase activity observed for thrombin-stimulated platelets. In the absence of added factor Va, C5b-9 assembly on the platelet surface significantly shortened the lag period before prothrombinase expression that was observed for untreated platelets and increased the maximum catalytic rate of thrombin formation. A comparison with other platelet stimuli revealed that the C5b-9-induced activation of platelet prothrombinase closely paralleled the effects mediated by calcium ionophore A23187. Our data suggest that the C5b-9 proteins promote the release of platelet factor V and the assembly of the prothrombinase complex, thereby potentiating the effects of thrombin on the activation of prothrombinase. Membrane assembly of the C5b-9 proteins was also observed to markedly accelerate the rate of platelet-catalyzed plasma clotting, suggesting a direct link between C5b-9-mediated prothrombinase activation and procoagulant activity accompanying immunologic damage to the platelet.
Related Links	https://ashpublications.org/blood/article-pdf/68/4/875/363983/875.pdf
Ending Page	880
Page Count	6
Starting Page	875
DOI	10.1182/blood.v68.4.875.bloodjournal684875
Journal	Blood
Issue Number	4
Volume Number	68
Language	English
Publisher	American Society of Hematology
Publisher Date	1986-10-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Proteins C5b Platelet Catalyzed Clot Prothrombinase Activation Procoagulant Activity Journal: Blood (Vol- 75, Issue- 4)
Content Type	Text
Resource Type	Article

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