Cytogenetic studies and their prognostic significance in agnogenic myeloid metaplasia: a report on 47 cases

Content Provider	Scilit
Author	Demory, Jl Dupriez, B. Fenaux, P. Lai, Jl Beuscart, R. Jouet, Jp Deminatti, M. Bauters, F.
Copyright Year	1988
Description	Cytogenetic analysis was performed in 47 newly diagnosed patients with agnogenic myeloid metaplasia (AMM); 32 had a normal karyotype (68%, group I), whereas 15 had clonal abnormalities (32%, group II). The most frequent abnormal findings were a 20q- deletion in six cases (either alone or within complex anomalies), interstitial 13q- deletion in three cases (and monosomy 13 in one case), and acquired trisomy 21 or 21p+ in three cases. Four cases exhibited complex aberrations involving several chromosomes, sometimes with a mosaicism. In two patients with an initial abnormal karyotype, further cytogenetic analysis during the disease course showed the appearance of additional clonal anomalies, and particularly of a probable Philadelphia (Ph1) variant in one case. Treatment was essentially supportive. Survival was significantly shorter in group II (median, 30 months) compared with group I (median, not reached at 6 years; P = .015). In univariate analysis, other parameters significantly associated with a poor prognosis (P less than .05) were higher age, anemia, and increased percentage of circulating blasts. However, in a multivariate analysis, only cytogenetic abnormalities and age retained their independent prognostic value.
Related Links	https://ashpublications.org/blood/article-pdf/72/3/855/449836/855.pdf
Ending Page	859
Page Count	5
Starting Page	855
DOI	10.1182/blood.v72.3.855.855
Journal	Blood
Issue Number	3
Volume Number	72
Language	English
Publisher	American Society of Hematology
Publisher Date	1988-09-01
Access Restriction	Open
Subject Keyword	Dermatology Hematology Multivariate Analysis Treatment Survival Prognostic Abnormal Myeloid Metaplasia Cytogenetic Deletion Agnogenic Journal: Blood (Vol- 67, Issue- 3)
Content Type	Text
Resource Type	Article