NDLI: Gova/b alloantigen system on human platelets

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Gova/b alloantigen system on human platelets

Content Provider	Scilit
Author	Kelton, Jg Smith, Jw Horsewood, P. Humbert, Jr Hayward, Cp Warkentin, Te
Copyright Year	1990
Description	In this report we describe a platelet alloantigen system that is carried on a novel platelet protein of 175 Kd. Antisera against the two alleles (Gova/Govb) were found in two patients who had received large numbers of platelet transfusions. The anti-Gov alloantibodies could not be detected using a whole platelet solid phase enzyme immunoassay, or by a platelet glycoprotein capture enzyme immunoassay using monoclonal antibodies against glycoproteins Ib/IX, Ia/IIa, and IIb/IIIa. Using radioimmunoprecipitation techniques, a protein was precipitated that migrated at 175 Kd (reduced). Under nonreduced conditions, a 150-Kd protein was detected with a minor component at 175Kd. The detection of the alloantigens was not activation-dependent. Using immunodepletion studies, we demonstrated that each alloantiserum recognized an epitope on a discrete population of the 175-Kd platelet protein. Family studies demonstrated that the alloantigens designated as Gova and Govb were inherited in an autosomal codominant fashion. The phenotypic frequencies were Gova/Gova, 26%; Gova/Govb, 55%; Govb/Govb, 19%; giving gene frequencies of 0.532 and 0.468 for Gova and Govb, respectively (n = 33).
Related Links	https://ashpublications.org/blood/article-pdf/75/11/2172/210088/2172.pdf
Ending Page	2176
Page Count	5
Starting Page	2172
DOI	10.1182/blood.v75.11.2172.bloodjournal75112172
Journal	Blood
Issue Number	11
Volume Number	75
Language	English
Publisher	American Society of Hematology
Publisher Date	1990-06-01
Access Restriction	Open
Subject Keyword	Hematology Antibodies Glycoprotein Alloantigen Frequencies Platelet Protein Gova/govb Journal: Blood (Vol- 115, Issue- 11)
Content Type	Text
Resource Type	Article

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