On the mechanism of Hb F elevations in the baboon by erythropoietic stress and pharmacologic manipulation

Content Provider	Scilit
Author	Lavelle, D. DeSimone, J. Heller, P. Zwiers, D. Hall, L.
Copyright Year	1986
Description	Maximal fetal hemoglobin (Hb F) elevations in the baboon subsequent to phenyl hydrazine-induced hemolytic anemia, bleeding, bleeding plus hydroxyurea (HU), or cytosine arabinoside were two to three times lower than those achieved with bleeding plus 5-azacytidine (azaC). Because, in the baboon, maximal elevations in F cell numbers occurred with bleeding alone, changes in the levels of Hb F in hemolysates and in Hb F per F cell could be considered to be due to the administered drugs. Erythropoietic toxicity of azaC was minimal, making it unlikely that the marked elevations of Hb F were due to shifts in the population of erythroid progenitors and precursors and more likely that they were related to a biochemical effect of the drug on DNA. The data indicate marked DNA hypomethylation. This was also found to be associated, but to a much lesser extent, with the modest Hb F elevations after bleeding, hemolysis, and treatment with HU. This drug had greater erythroid toxicity than azaC, and it appeared that the Hb F elevations occurred mainly on the rebound from the early cytotoxicity. The explanation of the molecular DNA changes with this drug and in erythropoietic stress alone remains unknown.
Related Links	https://ashpublications.org/blood/article-pdf/67/4/1083/214154/1083.pdf
Ending Page	1089
Page Count	7
Starting Page	1083
DOI	10.1182/blood.v67.4.1083.bloodjournal6741083
Journal	Blood
Issue Number	4
Volume Number	67
Language	English
Publisher	American Society of Hematology
Publisher Date	1986-04-01
Access Restriction	Open
Subject Keyword	Hematology Stress Treatment Bleeding Baboon Erythroid Erythropoietic Plus Azac Hb F Elevations Journal: Blood (Vol- 75, Issue- 4)
Content Type	Text
Resource Type	Article