NDLI: Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/m2) in acute promyelocytic leukemia

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Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/m2) in acute promyelocytic leukemia

Content Provider	Scilit
Author	Castaigne, S. Lefebvre, P. Chomienne, C. Suc, E. Rigal-Huguet, F. Gardin, C. Delmer, A. Archimbaud, E. Tilly, H. Janvier, M.
Copyright Year	1993
Description	It has been shown that all-trans retinoic acid (ATRA) at doses of 45 to 100 mg/m2/d induces complete remission (CR) of acute promyelocytic leukemia (APL) by a differentiation process. To date, ATRA dose-ranging studies have not yet been evaluated. Thus, we initiated in May 1990 a multicenter study with ATRA at a lower dose of 25 mg/m2/d until CR. Thirty patients with APL were treated with ATRA, of whom 12 were previously untreated, 14 were in first relapse, and 4 had failed after conventional first induction chemotherapy. Twenty-four of 30 achieved CR, 3 failed, and 3 died before day 30. Median time to CR was 45 days. Hyperleucocytosis (14 to 43 x 10(9) white blood cells per liter) was observed in 9 patients between days 10 and 23. Clinical complications that may have been related to the retinoic acid syndrome were observed in 8 patients, of whom 3 died. Pharmacokinetics studies were performed in 5 patients. Peak plasma concentrations and mean area under the concentration-time curve were not lower than previous levels obtained under the 45 mg/m2 dose. Overall, our study shows that there is no difference in terms of therapeutic efficacy, triggering of hyperleukocytosis, or retinoic acid syndrome and pharmacokinetic results with ATRA at 25 or 45 mg/m2/d.
Related Links	https://ashpublications.org/blood/article-pdf/82/12/3560/227203/3560.pdf
Ending Page	3563
Page Count	4
Starting Page	3560
DOI	10.1182/blood.v82.12.3560.bloodjournal82123560
Journal	Blood
Issue Number	12
Volume Number	82
Language	English
Publisher	American Society of Hematology
Publisher Date	1993-12-15
Access Restriction	Open
Subject Keyword	Hematology Pharmacokinetics Differentiation Efficacy Trans Leukemia Retinoic Acid Atra Failed Apl Journal: Blood (Vol- 119, Issue- 12)
Content Type	Text
Resource Type	Article

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