Loading...
Please wait, while we are loading the content...
Similar Documents
Tribbles in acute leukemia
| Content Provider | Scilit |
|---|---|
| Author | Liang, Kai Ling Rishi, Loveena Keeshan, Karen |
| Copyright Year | 2013 |
| Description | There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial. |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/121/21/4265.full.pdf |
| Ending Page | 4270 |
| Page Count | 6 |
| Starting Page | 4265 |
| DOI | 10.1182/blood-2012-12-471300 |
| Journal | Blood |
| Issue Number | 21 |
| Volume Number | 121 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2013-05-23 |
| Access Restriction | Open |
| Subject Keyword | Hematology Research and Experimental Medicine Hematopoietic Acute Leukemia Tribbles Lymphoblastic Dysregulated Malignancies Pseudokinases Subtypes Oncogenic Journal: Blood (Vol- 133, Issue- 21) |
| Content Type | Text |
| Resource Type | Article |