Loading...
Please wait, while we are loading the content...
Similar Documents
Abnormal erythroid maturation in mice induced by isoniazid
| Content Provider | Scilit |
|---|---|
| Author | Morse, Bs Guiliani, D. Minak, V. Nussbaum, M. |
| Copyright Year | 1975 |
| Description | Defective arythropoiesis characterizes the sideroblastic anemias. The present studies were undertaken to assess the effects of isoniazid, an inhibitor of heme synthesis, on erythropoietin-induced erythroid maturation in hypertransfused mice. Isoniazid was administered at intervals during a wave of induced erythropoiesis, and the effects were assessed in both the bone marrow and peripheral blood. The data showed that isoniazid interfered with heme synthesis and erythroid maturation. The most inhibitory effect of isoniazid was noted at the intermediate normoblast stage. A transient increase in the reticulocyte nonheme iron pool was also found. |
| Related Links | https://ashpublications.org/blood/article-pdf/46/4/625/579472/625.pdf |
| Ending Page | 629 |
| Page Count | 5 |
| Starting Page | 625 |
| DOI | 10.1182/blood.v46.4.625.625 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 46 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1975-10-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Defective Isoniazid Erythropoiesis Nonheme Undertaken Erythroid Maturation Normoblast Journal: Blood (Vol- 74, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |