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MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells
| Content Provider | Scilit |
|---|---|
| Author | Liu, Suiyang Yin, Li Stroopinsky, Dina Rajabi, Hasan Puissant, Alexandre Stegmaier, Kimberly Avigan, David Kharbanda, Surender Kufe, Donald Stone, Richard |
| Copyright Year | 2014 |
| Description | Key Points The MUC1-C oncoprotein is aberrantly expressed in AML cells and contributes to activation of the mutant FLT3 receptor. Targeting MUC1-C thus inhibits FLT3 signaling and represents a potential approach for AML cells resistant to FLT3 inhibitors. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907758/pdf |
| Ending Page | 742 |
| Page Count | 9 |
| Starting Page | 734 |
| DOI | 10.1182/blood-2013-04-493858 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 123 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2014-01-30 |
| Access Restriction | Open |
| Subject Keyword | Hematology Muc1 Oncoprotein Leukemia Myeloid Aberrantly Flt3 Receptor Aml Cells Journal: Blood (Vol- 84, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |