NDLI: The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis

Content Provider	Scilit
Author	Deininger, Michael Radich, Jerald Burn, Timothy C. Huber, Reid Paranagama, Dilan Verstovsek, Srdan
Copyright Year	2015
Description	Key Points The JAK2p.V617F mutation leads to constitutive activation of JAK2 and contributes to dysregulated JAK signaling in myelofibrosis. Long-term ruxolitinib treatment decreased JAK2p.V617F allele burden, with some patients achieving complete or partial molecular remissions.
Related Links	http://www.bloodjournal.org/content/bloodjournal/126/13/1551.full.pdf
Ending Page	1554
Page Count	4
Starting Page	1551
DOI	10.1182/blood-2015-03-635235
Journal	Blood
Issue Number	13
Volume Number	126
Language	English
Publisher	American Society of Hematology
Publisher Date	2015-09-24
Access Restriction	Open
Subject Keyword	Hematology Myelofibrosis Allele Burden C.1849g Jak2p.v617f Allele Ruxolitinib Treatment Journal: Blood (Vol- 123, Issue- 13)
Content Type	Text
Resource Type	Article

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