Immunoglobulin secretory function of B cells from untreated patients with chronic lymphocytic leukemia and hypogammaglobulinemia: role of T cells

Content Provider	Scilit
Author	Fernandez, La Macsween, Jm Langley, Gr
Copyright Year	1983
Description	The mechanism of the hypogammaglobulinemia in patients with chronic lymphocytic leukemia (CLL) was studied by determining the generation of specific immunoglobulin-secreting cells in response to mitogen and antigen stimulation in culture. Normal peripheral blood B lymphocytes from 18 normal subjects cocultured with equal numbers of autologous T cells generated cells secreting 2,542 +/- 695 IgG, 2,153 +/- 615 IgA, and 2,918 +/- 945 IgM. Normal B lymphocytes cocultured with normal allogeneic T cells generated similar numbers. However, B lymphocytes from patients with chronic lymphocytic leukemia cocultured with T cells from the same patient generated only 0.5% as many cells secreting IgG and 11% and 23% as many secreting IgA and IgM, respectively. The reason for this markedly defective generation of immunoglobulin-secreting cells was investigated by evaluating T-helper, T-suppressor, and B-cell function using B cells from tonsil and T and B cells from peripheral blood of normal and leukemic individuals. T cells from patients with chronic lymphocytic leukemia provided somewhat greater help than did normal T cells to normal peripheral blood B cells and normal help to tonsil B cells, whether stimulated with mitogen or antigen. T cells from patients with chronic lymphocytic leukemia did not demonstrate increased suppressor function compared to normals with B cells from normal peripheral blood. The hypogammaglobulinemia in these patients therefore was associated with a markedly defective generation of immunoglobulin secreting cells, and as there was normal or increased T- cell helper activity without excessive suppressor activity, it seems likely that this was due to an intrinsic B-cell defect.
Related Links	https://ashpublications.org/blood/article-pdf/62/4/767/211714/767.pdf
Ending Page	774
Page Count	8
Starting Page	767
DOI	10.1182/blood.v62.4.767.bloodjournal624767
Journal	Blood
Issue Number	4
Volume Number	62
Language	English
Publisher	American Society of Hematology
Publisher Date	1983-10-01
Access Restriction	Open
Subject Keyword	Hematology Function Antigen Chronic Lymphocytic Leukemia Secreting Cells Patients with Chronic Journal: Blood (Vol- 75, Issue- 4)
Content Type	Text
Resource Type	Article