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Influence of HLA-A2 on the effectiveness of platelet transfusions in alloimmunized thrombocytopenic patients
| Content Provider | Scilit |
|---|---|
| Author | Duquesnoy, Rj Filip, Dj Aster, Rh |
| Copyright Year | 1977 |
| Description | Platelet transfusions from donors selectively mismatched for cross- reactive and certain non-cross-reactive HLA antigens were found to be more effective in HLA-A2 negative than in HLA-A2 positive, alloimmunized thrombocytopenic patients. The two groups of patients responded equally well to platelets matched for antigens of the HLA-A and B loci. Certain alloimmunized patients negative for HLA-A2 continued to respond satisfactorily to platelets selectively mismatched for non-cross-reactive HLA antigens as long as platelets containing HLA- A2 were avoided. The data indicate that platelet transfusion support can be provided within a broader range of donor-recipient HLA antigenic disparity to HLA-A2 negative alloimmunized patients than to those who are positive for this antigen. |
| Related Links | https://ashpublications.org/blood/article-pdf/50/3/407/205794/407.pdf |
| Ending Page | 412 |
| Page Count | 6 |
| Starting Page | 407 |
| DOI | 10.1182/blood.v50.3.407.bloodjournal503407 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 50 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1977-09-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Platelets Platelet Transfusion Donor Hla Antigens Transfusions Alloimmunized Hla A2 Journal: Blood (Vol- 64, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
