Use of recombinant human erythropoietin in allogeneic bone marrow transplant donor/recipient pairs

Content Provider	Scilit
Author	Mitus, Aj Antin, Jh Rutherford, Cj Mcgarigle, Cj Goldberg, Ma
Copyright Year	1994
Description	In an attempt to reduce or eliminate homologous red blood cell transfusion requirements during allogeneic bone marrow transplantation (BMT), we instituted a novel program whereby recombinant human erythropoietin was administered to pairs of BMT donors and recipients. Eleven recipients and their HLA-matched donors were enrolled. Donors treated with recombinant human erythropoietin (rHuEPO) were phlebotomized a median of 6 U (range, 4 to 11 U) of blood over a 5-week period. This donor-derived blood was available to the BMT donor or recipient as needed. Transplant recipients were also treated with rHuEPO post-BMT to hasten erythropoiesis. Five of 11 BMT recipients underwent transplant receiving only donor-derived red blood cell transfusion, compared with 0 of 11 concomitant control recipients (P = .04). In addition, the time to absolute reticulocyte count > or = 10(4)/microL was statistically shorter in the rHuEPO-treated recipient group. This study serves as a paradigm for hematopoietic growth factor use in allogeneic BMT to decrease or eliminate homologous transfusion exposures and to possibly hasten hematopoietic engraftment.
Related Links	https://ashpublications.org/blood/article-pdf/83/7/1952/230596/1952.pdf
Ending Page	1957
Page Count	6
Starting Page	1952
DOI	10.1182/blood.v83.7.1952.bloodjournal8371952
Journal	Blood
Issue Number	7
Volume Number	83
Language	English
Publisher	American Society of Hematology
Publisher Date	1994-04-01
Access Restriction	Open
Subject Keyword	Hematology Hematopoietic Transplant Bone Marrow Allogeneic Recipients Bmt Recombinant Homologous Donor Hasten Journal: Blood (Vol- 97, Issue- 7)
Content Type	Text
Resource Type	Article