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Prevention of HLA immunization with leukocyte-poor packed red cells and platelet concentrates obtained by filtration
| Content Provider | Scilit |
|---|---|
| Author | Andreu, G. Dewailly, J. Leberre, C. Quarre, Mc Bidet, Ml Tardivel, R. Devers, L. Lam, Y. Soreau, E. Boccaccio, C. |
| Copyright Year | 1988 |
| Description | HLA immunization is a common complication of transfusion therapy in 30% to 60% of oncohematologic patients. Evidence shows that leukocytes present in cellular blood products are the main component involved in the occurrence of HLA immunization, and several studies showed that leukocyte-poor blood products are less able to induce it. However, leukocyte-poor platelet concentrates obtained by conventional techniques, ie, centrifugation, frequently have a high level of remaining leukocytes. Cotton wool filter Imugard IG 500 can be used to obtain leukocyte-poor cellular blood products. The technique is easy to perform, even in an emergency, and can be used with either packed RBCs or platelet concentrates. Means of 97%, 92%, and 76% elimination of leukocytes are obtained for packed RBCs, pooled standard platelet concentrates, and single-donor platelet concentrates, respectively. Patients were randomized to receive either standard (control group) or filtered (leukocyte-poor group) blood products. Of 112 randomized patients, 69 were evaluable, 35 in the control group and 34 in the leukocyte-poor group. Both groups are comparable according to age, diagnosis, sex ratio, previous transfusions, and pregnancies. There is a significant difference in regard to the HLA immunization rate (31.4% in the control v 11.7% in the leukocyte-poor group, P less than .05) and frequency of refractoriness to platelet transfusions (46.6% v 11.7%, P less than .05). We conclude that this filtration technique can be an efficient means to reduce the HLA immunization rate in polytransfused oncohematologic patients. |
| Related Links | https://ashpublications.org/blood/article-pdf/72/3/964/449796/964.pdf |
| Ending Page | 969 |
| Page Count | 6 |
| Starting Page | 964 |
| DOI | 10.1182/blood.v72.3.964.964 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-09-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Platelet Concentrates Transfusions Blood Products Leukocyte Poor Packed Hla Immunization Journal: Blood (Vol- 67, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
