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Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody
| Content Provider | Scilit |
|---|---|
| Author | McFarland, Jg Blanchette, V. Collins, J. Newman, Pj Wang, R. Aster, Rh |
| Copyright Year | 1993 |
| Description | An infant with severe neonatal alloimmune thrombocytopenia is described in whom an antibody directed at a new platelet-specific alloantigen, Ca (HPA-6b), is implicated. The new alloantigen is of low frequency in the population and was localized to platelet glycoprotein (GP) IIIa. Immunoprecipitation studies using murine monoclonal antibodies specific for the GP complex IIb-IIIa and GPIIIa alone (AP2 and AP3) suggest that the location of the Ca epitope on GPIIIa may be near the binding site for AP3. Neonatal alloimmune thrombocytopenia associated with Ca is likely to be as severe as that seen in cases due to incompatibilities for the HPA-1 (PIA) and HPA-4 (Pen) platelet alloantigen systems, because each is located on GPIIIa, a densely represented molecule on the platelet surface. |
| Related Links | https://ashpublications.org/blood/article-pdf/81/12/3318/610426/3318.pdf |
| Ending Page | 3323 |
| Page Count | 6 |
| Starting Page | 3318 |
| DOI | 10.1182/blood.v81.12.3318.3318 |
| Journal | Blood |
| Issue Number | 12 |
| Volume Number | 81 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1993-06-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Pediatrics and Child Health Antibody Platelet Neonatal Alloimmune Thrombocytopenia Alloantigen Iiia Journal: Blood (Vol- 119, Issue- 12) |
| Content Type | Text |
| Resource Type | Article |
