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High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease
| Content Provider | Scilit |
|---|---|
| Author | Burt, Richard K. Traynor, Ann Oyama, Yu Craig, Robert |
| Copyright Year | 2003 |
| Description | Two patients with severe Crohn disease, defined by a Crohn Disease Activity Index (CDAI) higher than 250 despite anti–tumor necrosis factor α (TNF-α), were treated by intense immune suppression and autologous hematopoietic stem cell transplantation (HSCT). Stem cells were mobilized from the peripheral blood using cyclophosphamide (2.0 g/m2) and granulocyte colony-stimulating factor (G-CSF; 5 μg/kg/d), enriched ex vivo by CD34+ selection, and reinfused after immune conditioning with cyclophosphamide (200 mg/kg) and equine anti–thymocyte globulin (ATG; 90 mg/kg). Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted. |
| Related Links | http://pdfs.semanticscholar.org/da11/1be8c7ab264e1079a825ddf0f30be01f760f.pdf |
| Ending Page | 2066 |
| Page Count | 3 |
| Starting Page | 2064 |
| DOI | 10.1182/blood-2002-07-2122 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 101 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2003-03-01 |
| Access Restriction | Open |
| Subject Keyword | Gastroenterology and Hepatology Hematopoietic Hsct Stem Transplantation Crohn Disease Autologous Cyclophosphamide Mg/kg Journal: Blood (Vol- 84, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
