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T lymphocytes from invaded lymph nodes in patients with B-cell-derived non-Hodgkin's lymphoma: reactivity toward the malignant clone
| Content Provider | Scilit |
|---|---|
| Author | Jacob, Mc Piccinni, Mp Bonnefoix, T. Sotto, Mf Couderc, P. Bensa, Jc Sotto, Jj |
| Copyright Year | 1990 |
| Description | Tumor-infiltrating T lymphocytes (TIL-T) are always present in B-cell- derived non-Hodgkin's lymphoma (NHL). In this investigation, we explored the possibility that collaboration might exist between these cells. TIL-T were isolated from 39 lymph nodes of patients with NHL. In most of the cases, few of them (less than 10%) possessed surface activation receptors CD25 or OKT9. In 80% of the cases, they proliferated in response to recombinant interleukin-2 (rIL-2), but the degree of proliferation was often low as compared with control populations. The influence of irradiated autologous malignant cells on the TIL-T proliferation in response to rIL-2 (40 U/mL) was also investigated: in 38% of the cases, this proliferation was not modified (group O), and in 41% it was higher (group +) and in 21% it was lower (group -). The mechanism of this immune response (specific or not) is not elucidated at present. The definition of these groups was statistically correlated with different parameters of the disease: (1) percentage of TIL-T was higher in group + (44% +/- 17%) than in group O (31% +/- 18%) and group - (24% +/- 15%); (2) B-cell proliferation in centrofollicular lymphomas was more frequently nodular or nodular and diffuse in group + (83%) and O (55%) than in group - (0%); (3) low- grade malignancies in the Working Formulation were more frequent in group + (75%) than in group O (60%) or group - (12%); (4) favorable prognosis evaluated with the Grenoble cytologic classification was more frequent in group + and O (87%) than in group - (12%); (5) actuarial survival curves showed a significantly better prognosis for patients in group +. |
| Related Links | https://ashpublications.org/blood/article-pdf/75/5/1154/217310/1154.pdf |
| Ending Page | 1162 |
| Page Count | 9 |
| Starting Page | 1154 |
| DOI | 10.1182/blood.v75.5.1154.bloodjournal7551154 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 75 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1990-03-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Lymphocytes Prognosis Lymphoma Malignant Til Nodular Nhl Hodgkin's Ril Journal: Blood (Vol- 82, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
