NDLI: Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

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Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

Content Provider	Scilit
Author	Cooper, Megan Fehniger, Todd Turner, Sarah C. Chen, Kenneth Ghaheri, Bobak A. Ghayur, Tariq Carson, Iii William E. Caligiuri, Michael A.
Copyright Year	2001
Description	During the innate immune response to infection, monocyte-derived cytokines (monokines), stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important to the host's early defense. Human NK cell subsets can be distinguished by CD56 surface density expression (ie, CD56bright and CD56dim). In this report, it is shown that CD56bright NK cells produce significantly greater levels of interferon-γ, tumor necrosis factor-β, granulocyte macrophage–colony-stimulating factor, IL-10, and IL-13 protein in response to monokine stimulation than do CD56dim NK cells, which produce negligible amounts of these cytokines. Further, qualitative differences in CD56bright NK-derived cytokines are shown to be dependent on the specific monokines present. For example, the monokine IL-15 appears to be required for type 2 cytokine production by CD56bright NK cells. It is proposed that human CD56bright NK cells have a unique functional role in the innate immune response as the primary source of NK cell–derived immunoregulatory cytokines, regulated in part by differential monokine production.
Related Links	http://www.bloodjournal.org/content/97/10/3146.full.pdf
Ending Page	3151
Page Count	6
Starting Page	3146
DOI	10.1182/blood.v97.10.3146
Journal	Blood
Issue Number	10
Volume Number	97
Language	English
Publisher	American Society of Hematology
Publisher Date	2001-05-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Protein Immune Response Functional Differential Innate Immune Subset Killer Cd56bright Monokine Journal: Blood (Vol- 113, Issue- 10)
Content Type	Text
Resource Type	Article

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