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Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets
| Content Provider | Scilit |
|---|---|
| Author | Gralnick, Hr Williams, Sb Shafer, Bc Corash, L. |
| Copyright Year | 1982 |
| Description | A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia. We have found that these platelets bind more of the normal and intermediate-sized multimers of the factor VIII/von Willebrand factor than normal platelets. Analysis of the binding data show an increased affinity of these vWd platelets for the factor VIII/von Willebrand factor. These findings are consistent with an increased number of platelet receptors, which, either by their native topography or migration on the platelet surface, bind factor VIII/von Willebrand factor protein with greater affinity than normal platelets, platelets of other vWd patients, and large platelets of other etiologies. |
| Related Links | https://ashpublications.org/blood/article-pdf/60/2/328/211139/328.pdf |
| Ending Page | 332 |
| Page Count | 5 |
| Starting Page | 328 |
| DOI | 10.1182/blood.v60.2.328.bloodjournal602328 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 60 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1982-08-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Protein Platelets Willebrand's Disease Willebrand Factor Factor Viii/von Viii/von Willebrand Von Willebrand's Journal: Blood (Vol- 50, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
