NDLI: Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia

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Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia

Content Provider	Scilit
Author	O'brien, Susan M. Ferrajoli, Alessandra Lee, Bang-Ning Schlette, Ellen J. Gao, Hui Wen, Sijin Wierda, William G. Estrov, Zeev Faderl, Stefan Cohen, Evan Li, Changping Reuben, James M. Keating, Michael J.
Copyright Year	2008
Description	This study investigated the activity of lenalidomide in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Lenalidomide was given at 10 mg daily with dose escalation up to 25 mg daily. Three patients (7%) achieved a complete response (CR), one a nodular partial remission, and 10 patients a partial remission (PR), for an overall response (OR) rate of 32%. Treatment with lenalidomide was associated with an OR rate of 31% in patients with 11q or 17p deletion, of 24% in patients with unmutated VH, and of 25% in patients with fludarabine-refractory disease. The most common toxicity was myelosuppression, and the median daily dose of lenalidomide tolerated was 10 mg. Plasma levels of angiogenic factors, inflammatory cytokines, and cytokine receptors were measured at baseline, day 7, and day 28. There was a dramatic increase in median interleukin (IL)-6, IL-10, IL-2, and tumor necrosis factor receptor-1 levels on day 7, whereas no changes were observed in median vascular endothelial growth factor levels (20 patients studied). According to our experience, lenalidomide given as a continuous treatment has antitumor activity in heavily pretreated patients with CLL. This trial is registered at http://www.clinicaltrials.gov as no. NCT00267059.
Related Links	http://www.bloodjournal.org/content/111/11/5291.full.pdf
Ending Page	5297
Page Count	7
Starting Page	5291
DOI	10.1182/blood-2007-12-130120
Journal	Blood
Issue Number	11
Volume Number	111
Language	English
Publisher	American Society of Hematology
Publisher Date	2008-06-01
Access Restriction	Open
Subject Keyword	Hematology Treatment Refractory Leukemia Lymphocytic Cll Lenalidomide Partial Remission Tolerated Journal: Blood (Vol- 117, Issue- 11)
Content Type	Text
Resource Type	Article

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