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Clinical developments in epigenetic-directed therapies in acute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Pan, Darren Rampal, Raajit Mascarenhas, John |
| Copyright Year | 2020 |
| Description | Acute myeloid leukemia (AML) is a highly heterogeneous disease arising from acquired genetic and epigenetic aberrations which stifle normal development and differentiation of hematopoietic precursors. Despite the complex and varied biological underpinnings, induction therapy for AML has remained fairly uniform over 4 decades and outcomes remain poor for most patients. Recently, enhanced understanding of the leukemic epigenome has resulted in the translational investigation of a number of epigenetic modifying agents currently in various stages of clinical development. These novel therapies are based on mechanistic rationale and offer the potential to improve AML patient outcomes. In light of many recent advances in this field, we provide an updated, clinically oriented review of the evolving landscape of epigenetic modifying agents for the treatment of AML. |
| Related Links | https://ashpublications.org/bloodadvances/article-pdf/4/5/970/1719873/advancesadv2019001245.pdf |
| Ending Page | 982 |
| Page Count | 13 |
| Starting Page | 970 |
| DOI | 10.1182/bloodadvances.2019001245 |
| Journal | Blood advances |
| Issue Number | 5 |
| Volume Number | 4 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2020-03-10 |
| Access Restriction | Open |
| Subject Keyword | Hematology Differentiation Treatment Hematopoietic Epigenetic Outcomes Acute Myeloid Leukemia Aml Clinical Developments Journal: Blood advances (Vol- 79, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
