NDLI: Differential diagnosis of monoclonal gammopathy of undetermined significance

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Differential diagnosis of monoclonal gammopathy of undetermined significance

Content Provider	Scilit
Author	Merlini, Giampaolo Palladini, Giovanni
Copyright Year	2012
Description	Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma cell disorder occurring in 4.2% of adults > 50 years of age, which can progress into symptomatic diseases either through proliferation of the plasma cell clone, giving rise to multiple myeloma and other lymphoplasmacellular neoplasms, or through organ damage caused by the monoclonal protein, as seen in light-chain amyloidosis and related conditions. Differential diagnosis of asymptomatic and symptomatic monoclonal gammopathies is the determinant for starting therapy. The criteria for determining end-organ damage should include markers of organ injury caused by the monoclonal protein. Patient assessment and optimal follow-up are now performed using risk stratification models that should also take into account the risk of developing AL amyloidosis. Patients with low-risk MGUS (approximately 40% of all MGUS patients) need limited assessment and very infrequent follow-up. The ongoing development of novel molecular biomarkers and advanced imaging techniques will improve the identification of high-risk patients who may benefit from early therapeutic intervention through innovative clinical trials.
Related Links	https://ashpublications.org/hematology/article-pdf/2012/1/595/787060/bep00112000595.pdf
Ending Page	603
Page Count	9
Starting Page	595
DOI	10.1182/asheducation.v2012.1.595.3798563
Journal	Hematology
Issue Number	1
Volume Number	2012
Language	English
Publisher	American Society of Hematology
Publisher Date	2012-12-08
Access Restriction	Open
Subject Keyword	Hematology Medical Laboratory Technology Multiple Myeloma Diagnosis Models Adults Differential Mgus Optimal Symptomatic Protein Undetermined Journal: Hematology (Vol- 31, Issue- 1)
Content Type	Text
Resource Type	Article

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