NDLI: Expression of myelomonocytic antigens on chronic lymphocytic leukemia B cells correlates with their ability to produce interleukin 1

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Expression of myelomonocytic antigens on chronic lymphocytic leukemia B cells correlates with their ability to produce interleukin 1

Content Provider	Scilit
Author	Morabito, F. Prasthofer, Ef Dunlap, Ne Grossi, Ce Tilden, Ab
Copyright Year	1987
Description	We analyzed the expression of myelomonocytic-associated antigens on lymphocytes from B cell chronic lymphocytic leukemia (B-CLL) patients. Blood mononuclear cells were depleted of monocytes by one-step Percoll density gradient centrifugation and tested for antigen expression by fluorescent microscopy and flow cytometry. The reactivity of patient lymphocytes was as follows: 26 of 31 were positive for CD14 (Myr), 22 of 31 for a monocyte Fc receptor (MFC-1), 22 of 31 for CD11b (C3bi receptor), eight of 31 for CD15 (Leu-M1), five of 18 for CD13 (My 7), seven of 18 for My 9, and five of 30 for Mo 2. The B lymphocytes of B- CLL patients were also tested for the ability to produce interleukin 1 (IL-1) after depletion of monocytes and T lymphocytes. In 13 of 17 cases, B lymphocytes of patients produced IL-1 as detected in a mouse thymocyte proliferation assay and, in selected cases, a radioimmunoassay specific for IL-1 beta. The 13 cases that produced IL- 1 were also positive for the expression of one or more myelomonocytic- associated antigens, whereas the four cases that did not produce IL-1 lacked expression of these antigens. In conclusion, the malignant B cells of B-CLL patients frequently express a variety of antigens generally considered specific for myelomonocytic cells, and expression of these antigens is associated with the ability to produce IL-1.
Related Links	https://ashpublications.org/blood/article-pdf/70/6/1750/365578/1750.pdf
Ending Page	1757
Page Count	8
Starting Page	1750
DOI	10.1182/blood.v70.6.1750.bloodjournal7061750
Journal	Blood
Issue Number	6
Volume Number	70
Language	English
Publisher	American Society of Hematology
Publisher Date	1987-12-01
Access Restriction	Open
Subject Keyword	Hematology Monocytes Lymphocytes Leukemia Lymphocytic Cll Myelomonocytic Associated Antigens Journal: Blood (Vol- 88, Issue- 6)
Content Type	Text
Resource Type	Article

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