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G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity
| Content Provider | Scilit |
|---|---|
| Author | Baumeister, Susanne H. C. Hölig, Kristina Bornhäuser, Martin Meurer, Michael Rieber, E. Peter Schäkel, Knut |
| Copyright Year | 2007 |
| Description | Donor dendritic cells (DCs) play a pivotal role in the induction of immunity and tolerance after peripheral blood stem cell transplantation (PBSCT). Treatment of healthy donors with granulocyte-colony stimulating factor (G-CSF) increases the numbers of tolerogenic DCs and T cells among mobilized blood leukocytes in the graft. SlanDCs (6-sulfo LacNAc+ DCs), a major source of IL-12 and TNF-α in blood, have not been studied in this respect. Here, we demonstrate that slanDCs (14.9 × 106/L to 64.0 × 106/L) are efficiently mobilized by G-CSF and retain their capacity to produce IL-12 and TNF-α at high levels. Furthermore, G-CSF–mobilized slanDCs programmed the differentiation of Th1 cells and displayed a particularly strong capacity to stimulate the proliferation of naive allogeneic T cells. Thus, slanDCs transfused into recipients of allogeneic peripheral blood stem cell (PBSC) transplants are functionally fully capable and may be critical in supporting graft-versus-host disease as well as graft-versus-leukemia effects. |
| Related Links | http://pdfs.semanticscholar.org/4c1d/75c10e60cdbf97fbb2caf1267a6384023bd6.pdf |
| Ending Page | 3081 |
| Page Count | 4 |
| Starting Page | 3078 |
| DOI | 10.1182/blood-2006-12-062984 |
| Journal | Blood |
| Issue Number | 8 |
| Volume Number | 110 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2007-10-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Csf Transplantation Mobilized Slandcs Peripheral Blood Stem Cell Journal: Blood (Vol- 105, Issue- 8) |
| Content Type | Text |
| Resource Type | Article |
